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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Businessman and IPO virtual screen

Duchembio files for IPO to grow radiopharma business

Nov. 12, 2024
By Marian (YoonJee) Chu
Radiopharmaceutical biotech and contract development and organization firm Duchembio Co. Ltd. filed a securities report to South Korea’s Financial Services Commission Nov. 11, kickstarting the IPO process to list on the Korea Exchange.
Read More
Businessman and IPO virtual screen

Duchembio files for IPO to grow radiopharma business

Nov. 11, 2024
By Marian (YoonJee) Chu
Radiopharmaceutical biotech and contract development and organization firm Duchembio Co. Ltd. filed a securities report to South Korea’s Financial Services Commission Nov. 11, kickstarting the IPO process to list on the Korea Exchange.
Read More
Illustration of Microglia cells (red) in Alzheimer´s disease
Neurology/psychiatric

Less microglia activity may improve APOE4’s effect in Alzheimer’s

Nov. 8, 2024
By Mar de Miguel
Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s disease. By transplanting human neurons into the mouse brain and eliminating the mouse microglia, scientists at the Gladstone Institutes in San Francisco observed that amyloid and tau deposition was reduced. These results support therapeutic strategies that target APOE4 and microglia.
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Neurons with dendrites affected by amyloid plaques in Alzheimer's disease

Roche’s blood tests show high accuracy in detecting Alzheimer's disease

Nov. 6, 2024
By Shani Alexander
Data from two Alzheimer’s tests being developed by Roche Holding AG showed high accuracy in detecting the disease in patients being tested for the condition. The tests measure biomarkers in the blood linked to Alzheimer’s and will help provide desperately needed information by letting patients know whether they have the disease or not, Margherita Carboni, Neurology Indication Lead at Roche Diagnostics told BioWorld.
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Components of a radiopharmaceutical
KoNECT 2024

Panel discusses radiopharmaceuticals, oral small-molecule drugs for AD

Nov. 5, 2024
By Marian (YoonJee) Chu
A year out from Leqembi’s approval for Alzheimer’s disease (AD), ongoing research coupled with artificial intelligence is advancing both radiopharmaceuticals and small-molecule drugs for AD diagnostics and treatment, speakers at the 2024 KoNECT-MOHW-MFDS conference said.
Read More
Components of a radiopharmaceutical
KoNECT 2024

Panel discusses radiopharmaceuticals, oral small-molecule drugs for AD

Nov. 4, 2024
By Marian (YoonJee) Chu
A year out from Leqembi’s approval for Alzheimer’s disease (AD), ongoing research coupled with artificial intelligence is advancing both radiopharmaceuticals and small-molecule drugs for AD diagnostics and treatment, speakers at the 2024 KoNECT-MOHW-MFDS conference said.
Read More
AI generated, 3D rendering of protein degradation
Neurology/psychiatric

Biogen, Neomorph pact worth $1.45B for molecular glue degraders

Oct. 31, 2024
By Karen Carey
Two days after Monte Rosa Therapeutics Inc. signed a molecular glue degrader deal with Novartis AG, two other companies, Biogen Inc. and Neomorph Inc., are moving forward in the same space in a partnership worth up to $1.45 billion. Cambridge, Mass.-based Biogen and San Diego-based Neomorph will develop molecular glue degraders (MGDs) for priority targets in Alzheimer’s, rare neurological and immunological diseases, using Neomorph’s MGD platform to identify and validate novel small-molecule protein degraders.
Read More
Amyloid plaques on nerve cell

How now, tau? ‘Newer science’ shines in Lexeo Alzheimer’s data

Oct. 30, 2024
By Randy Osborne
The prospect of a gene therapy for Alzheimer’s disease has kept Wall Street steadily interested in Lexeo Therapeutics Inc., and another increment of intrigue was added when the New York-based firm  offered positive interim results from the 52-week, 15-subject phase I/II study of LX-1001 for the treatment of the condition when APOE4-associated.
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Coya sinks on phase II Alzheimer’s data, advances combo strategy

Oct. 29, 2024
By Karen Carey
While phase II results of Coya Therapeutics Inc.’s low-dose IL-2 drug, COYA-301, showed promise in Alzheimer’s disease patients when dosed every four weeks, it was the more frequent dosing of every two weeks that led to exhausted regulatory T cells and no benefits, driving down the company’s stock by nearly 28%.
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Abbvie snags Alzheimer’s candidate in $1.4B Aliada buyout

Oct. 28, 2024
By Jennifer Boggs
Only three years after it was co-founded by Johnson & Johnson, Aliada Therapeutics Inc. is being acquired by Abbvie Inc. in a deal valued at $1.4 billion that gives the big pharma firm another shot at the Alzheimer’s disease space. The all-cash deal, expected to close in the fourth quarter of 2024, will give Abbvie access to Aliada’s blood-brain barrier-crossing Modular Delivery, or MODEL, as well as rights to ALIA-1758, an anti-pyroglutamate amyloid beta antibody designed using MODEL, which is in phase I testing for Alzheimer’s disease.
Read More
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