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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Elderly hands holding broken brain structure
Neurology/Psychiatric

STIM1 overexpression restores synaptic plasticity in female mice modeling Alzheimer’s disease

April 5, 2023
Gliotransmitter release by astrocytes depends on calcium dynamics and is an essential regulator of brain functions. Alterations of calcium homeostasis have been observed in neurons and astrocytes from mouse models of Alzheimer’s disease (AD). A new longitudinal study in the PS2APP mouse model of AD suggests a possible link between calcium dynamics in astrocytes and memory loss.
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Brain and DNA

Biorchestra inks potential $861M deal to develop therapies for neurological disorders

April 4, 2023
By Doris Yu
Biorchestra Co. Ltd. reached an exclusive research, option and licensing contract with a U.S.-based company to use its targeting technology platform to develop nucleic acid therapies to treat neurological disorders in a deal valued up to $861 million.
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Illustration of tau proteins in Alzheimer's disease
Neurology/Psychiatric

VXX-301, a tau vaccine with optimized properties

March 31, 2023
At the ongoing AD/PD meeting, researchers from Vaxxinity Inc. presented preclinical data for...
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Illustration of brain in head highlighting the blood-brain barier.
Neurology/Psychiatric

INR-301, a novel BBB-penetrating anti-PD-L1 antibody for the treatment of Alzheimer’s disease

March 30, 2023
Recent studies indicate that the hyperactivation of the PD-1/PD-L1 axis in Alzheimer’s disease (AD) brain has an influence on disease pathophysiology. With this in mind, researchers from Sungkyunkwan University evaluated INR-301, a novel superior blood-brain barrier (BBB)-penetrating anti-PD-L1 antibody, in an AD model.
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Speech Vitals-ALS mobile app

FDA grants Aural Analytics breakthrough device designation

March 29, 2023
By Annette Boyle
Aural Analytics Inc. received a breakthrough device designation from the U.S. FDA for its Speech Vitals-ALS technology, a software application that collects and analyzes speech recordings to help monitor amyotrophic lateral sclerosis (ALS) in adults in clinic and home settings. The software could improve management of the devastating disease.
Read More
Brain and DNA

Biorchestra inks potential $861M deal to develop therapies for neurological disorders

March 29, 2023
By Doris Yu
Biorchestra Co. Ltd. reached an exclusive research, option and licensing contract with a U.S.-based company to use its targeting technology platform to develop nucleic acid therapies to treat neurological disorders in a deal valued up to $861 million.
Read More
Neurology/Psychiatric

Biohaven licenses ex-China rights to Highlightll’s TYK2/JAK1 inhibitor for neurological disorders

March 23, 2023
Biohaven Ltd. has acquired global rights, excluding China regions, from Hangzhou Highlightll Pharmaceutical Co. Ltd. for TLL-041, now designated BHV-8000, an oral, brain-penetrant, highly selective, dual TYK2/JAK1 inhibitor, for neurological disorders.
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WDC 2023: New treatments a start, but more therapies needed for dementia

March 21, 2023
By Nuala Moran
FDA approval of Aduhelm (aducanumab), as the first disease modifying drug for Alzheimer’s, may have had a distinctly lukewarm reception in some quarters, but it is an important starting point in treating dementia, with a myriad of other avenues now being pursued in discovery and development.
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Brain with puzzle piece removed

WDC 2023: Entering a new era in preventing and treating dementia

March 21, 2023
By Nuala Moran
If you believe the theme of the World Dementia Council (WDC) meeting in London this week, dementia is “in a new era,” where it will be possible to prevent, diagnose and treat neurodegenerative disease. That is not the case for most people living with dementia today, but the approval of the first disease-modifying drugs and the imminent arrival of new blood-based biomarkers is “a big moment,” Lenny Shallcross, executive director of WDC told the meeting on Mar. 20.
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Brain with puzzle piece removed

WDC 2023: Entering a new era in preventing and treating dementia

March 20, 2023
By Nuala Moran
If you believe the theme of the World Dementia Council (WDC) meeting in London this week, dementia is “in a new era,” where it will be possible to prevent, diagnose and treat neurodegenerative disease. That is not the case for most people living with dementia today, but the approval of the first disease-modifying drugs and the imminent arrival of new blood-based biomarkers is “a big moment,” Lenny Shallcross, executive director of WDC told the meeting on Mar. 20.
Read More
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