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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Regenlife

Regenlife presents details of study examining efficacy of its photobiomodulation tech in Alzheimer’s

Dec. 5, 2022
By Bernard Banga
At the recent Clinic Trials on Alzheimer’s Disease (CTAD) conference in San Francisco, Regenlife SAS presented the design for its Light4life study examining the therapeutic efficacy of the RGn600 device. This trial on more than 100 subjects will evaluate the cognitive impacts of new photobiomodulation technology. 
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Porphyromonas gingivalis

Keystone Bio linking oral health with systemic benefit

Dec. 5, 2022
By Cormac Sheridan
The age-old separation of dentistry from medicine is deeply embedded in education and professional practice. Given the great advances in both disciplines in recent decades, there is a reasonable argument to be made for maintaining the divide.
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Woman and 3D brain

Anavex’s phase IIb/III study in AD hits its primary endpoint

Dec. 2, 2022
By Lee Landenberger
Anavex Life Sciences Corp. posted positive top-line data from its phase IIb/III study of ANAVEX 2-73-AD-004 (blarcamesine) in treating mild cognitive impairment due to Alzheimer’s disease (AD) and mild AD. The oral small-molecule activator of the sigma-1 receptor (SIGMAR1) met the study’s primary endpoints and key secondary endpoint with statistically significant results.
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Brain connections
Neurology/Psychiatric

In AD, neural network dysfunction due to plaque damage

Dec. 1, 2022
By Anette Breindl
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
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Neurology/Psychiatric

Vigil Neuroscience presents new TREM2 agonists

Dec. 1, 2022
Vigil Neuroscience Inc. has synthesized triggering receptor expressed on myeloid cells 2 (TREM2) agonists reported to be useful for the treatment of frontotemporal dementia, multiple sclerosis, rheumatoid arthritis, stroke, prion infections, Parkinson's, Alzheimer's and Nasu-Hakola diseases.
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More clarity on lecanemab as Eisai and Biogen present trial data

Nov. 30, 2022
By Brian Orelli
Eisai Co. Ltd. and Biogen Inc. presented the full data set for the Clarity Alzheimer’s disease trial of lecanemab at the 2022 Clinical Trials on Alzheimer’s Disease, which was simultaneously published in the New England Journal of Medicine. The data supported the top-line results released in September 2022.
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Neurons and amyloid plaques

Amyloid plaques recast as cause of neural network dysfunction

Nov. 30, 2022
By Anette Breindl
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
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Cross section of brain
Neurology/Psychiatric

Researchers develop murine model of AD with late-onset cognitive impairment

Nov. 30, 2022
Alzheimer’s disease (AD) is still the most prevalent neurodegenerative disorder, with few FDA-approved treatments and many that have failed; further understanding of AD’s disease mechanisms is required. Investigators from Gempharmatech Inc. have developed a novel AD murine model (FAD4T) in which APP (Swedish and Indiana mutations) and PSEN1 M146L/L286V mutations were inserted into the mice’s genome.
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Amyloid plaque on nerve cell

Two deaths reported ahead of Eisai-Biogen’s presentation of phase III data on Alzheimer’s drug lecanemab

Nov. 29, 2022
By Lee Landenberger
The shadow of two reported patients’ deaths hovers over Eisai Co Ltd. and Biogen Inc.’s Alzheimer’s disease treatment, lecanemab, as the companies prepare to present phase III study data on the drug later today at the 15th Clinical Trials on Alzheimer's Disease conference.
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Cajal raises $96M to accelerate neurodegeneration drug discovery

Nov. 29, 2022
By Michael Fitzhugh
Cajal Neuroscience Inc., a startup seeking new targets to use in medicines for neurodegeneration, has launched with the completion of a $96 million series A financing led by The Column Group and Lux Capital. The company, inspired by the pioneering work of Santiago Ramón y Cajal, is focused on the "mechanistic, spatial and temporal complexity of neurodegeneration" to determine "how, where and when different mechanisms contribute to disease."
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