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Home » Alzheimer’s disease

Articles Tagged with ''Alzheimer’s disease''

Biogen logo

Biogen knocked by ‘negative trend vote’ for Alzheimer’s drug in Europe

Nov. 17, 2021
By Jennifer Boggs
A European approval for Alzheimer’s drug aducanumab by year-end looks even more in doubt. A week after being called in before the EMA’s Committee for Medicinal Products for Human Use (CHMP) for an oral explanation of the trial data, Biogen Inc. said it received a “negative trend vote” on the marketing authorization application. A formal opinion by the CHMP is expected at its December meeting, but analysts are not optimistic.
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Clinical research concept with medical icons on light bulb

Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets

Nov. 15, 2021
By Nuala Moran
LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd.’s new structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed at intractable and poorly drugged membrane and complex-bound protein targets. The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high unmet need.
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‘Unforced error’

As EMA’s CHMP delays recommendation, US skepticism abides about Aduhelm approval

Nov. 12, 2021
By Anette Breindl
Technically speaking, the scientific community as a whole cannot say for sure whether and how well Aduhelm (aducanumab, Biogen Inc./Eisai, Co., Ltd.) works. After all, two years after the initial report of the Engage and Emerge data at the 2019 Clinical Trials in Alzheimer’s Disease (CTAD), the full trial data have still not been published in a peer-reviewed publication. Which, of course, is one of the problems with Aduhelm.
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Aduhelm product image

European regulators put off decision on Biogen’s controversial Alzheimer’s drug

Nov. 12, 2021
By Richard Staines
European regulators have put off a decision on Biogen Inc and Eisai, Co. Ltd.’s controversial Alzheimer’s drug, aducanumab, for likely another month, after the companies announced further supportive data from a follow-up under review by the FDA.
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IPO puzzle pieces

In the Vaxxinity of success: $78M IPO prices low but stock trades high

Nov. 11, 2021
By Randy Osborne
Vaxxinity Inc. priced its IPO below the targeted range, selling 6 million shares (NASDAQ:VAXX) at $13 each for proceeds of $78 million, but came out of the gate impressively, closing at $16.55, up $3.55, or 27%, after reaching $22.77 during the day.
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CTAD 2021

Split results split reactions to Lauriet trial results

Nov. 10, 2021
By Anette Breindl
Investors were thrilled when Roche Holding AG subsidiary Genentech Inc. and AC Immune SA reported top-line results from the Lauriet trial on Aug. 31, giving a positive jolt to AC Immune’s stock on the day of the announcement. At the Clinical Trials in Alzheimer’s Disease 2021 meeting, the reaction of the medical community was more skeptical.
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Biogen investigating death, ARIA incidents in Aduhelm safety reports

Nov. 9, 2021
By Mari Serebrov
As part of its pharmacovigilance program for Alzheimer’s drug Aduhelm (aducanumab), Biogen Inc. is evaluating a handful of reports published in the FDA Adverse Event Reporting System Public Dashboard, including the Aug. 18 death of a 75-year-old woman with Alzheimer’s and other co-morbidities.
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Elderly hands holding broken brain structure

Plenty ventured, ‘milestone’ Gained? Phase II/III fails in AD but data bolster Cortexyme gingipain theory

Oct. 27, 2021
By Randy Osborne
What Cortexyme Inc.’s chief operating officer Christopher Lowe called “a giant step forward” in Alzheimer’s disease (AD) research with atuzaginstat (COR-388) was viewed differently by Wall Street, which walloped shares (NASDAQ:CRTX) by 76%, or $44.17, causing the stock to close at $13.51.
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Businesswoman pressing dollar sign on touchscreen

Cerecin raises $40M for Alzheimer’s phase III, preps for potential South Korean IPO

Oct. 20, 2021
By David Ho
Cerecin Inc. has raised $40 million in an oversubscribed round of financing, paving the way for a potential listing in South Korea. Proceeds of the financing will fund the expansion of the company’s current studies and support the planning and initiation of a global phase III study of its lead candidate, tricaprilin, in Alzheimer’s disease.
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Drug capsule spilling onto brain

A diuretic shows potential as an Alzheimer’s treatment

Oct. 12, 2021
By Lee Landenberger
Bumetanide, a diuretic pill commonly used for treating fluid retention for those with heart, kidney or liver disease, showed a significantly lower prevalence of Alzheimer’s disease in its users than those not taking it.
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