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Home » multiple myeloma

Articles Tagged with ''multiple myeloma''

3D illustration of interferon-alpha molecular structure
Cancer

Myeloma Investment Fund joins Nammi’s B round

Aug. 7, 2024
Nammi Therapeutics Inc. has announced a $1 million investment commitment by the Myeloma Investment Fund (MIF) in a $30 million series B financing round prior to the planned start of a first-in-human phase I study of the company’s QXL-138AM in patients with locally advanced unresectable and/or metastatic solid tumors and multiple myeloma.
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Multiple myeloma illustration
Cancer

Fibroblast growth factor traps have anti-myeloma activity

Aug. 6, 2024
Researchers from the University of Brescia have presented the discovery and preclinical characterization of novel fibroblast growth factor (FGF) trap small molecules, being developed for the treatment of multiple myeloma (MM).
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Multiple myeloma cells in the bone marrow.
Cancer

Targeting LILRB1 disrupts cholesterol homeostasis and promotes MM cell ferroptosis

July 17, 2024
Previous studies have suggested the importance of cholesterol metabolism in multiple myeloma (MM) cells. Since ferroptosis is closely related to lipid metabolism, researchers from Houston Methodist Research Institute aimed to investigate the crosstalk between metabolic reprogramming and ferroptosis in MM cells.
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Iaso buys out Innovent’s rights to CAR T Fucaso

July 9, 2024
By Tamra Sami
Nanjing, China-based Iaso Biotherapeutics Co. Ltd. has bought out global rights to human anti-B cell maturation antigen CAR T Fucaso (equecabtagene autoleucel) from partner Innovent Biologics Inc.
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Iaso buys out Innovent’s rights to CAR T Fucaso

July 8, 2024
By Tamra Sami
Nanjing, China-based Iaso Biotherapeutics Co. Ltd. has bought out global rights to human anti-B cell maturation antigen CAR T Fucaso (equecabtagene autoleucel) from partner Innovent Biologics Inc.
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Scientist, microscope and dropper
Immuno-oncology

Oncopeptides selects OPSP-1 as first drug candidate from SPiKE platform

June 27, 2024
Oncopeptides AB has selected its first candidate drug based on the company’s unique platform for small polypeptide-based innate killer engagers (SPiKE). The SPiKE platform uses multispecific constructs, able to bind to multiple targets simultaneously.
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Immuno-oncology

Blimp-1 ablation enhances antitumoral efficacy of ARI-0002-h CAR T cells

June 26, 2024
CAR T-cell therapy that targets BCMA is an effective option for treating relapsed/refractory multiple myeloma, but there is a lack of persistence due to the inability to develop a memory phenotype.
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Multiple myeloma illustration
Immuno-oncology

CSPC’s mRNA-LNP-based CAR T-cell therapy cleared to enter clinic in China for multiple myeloma

June 26, 2024
CSPC Pharmaceutical Group Ltd. has obtained clearance from China’s National Medical Products Administration (NMPA) to conduct clinical trials in China with the first mRNA-lipid nanoparticles (LNP)-based CAR T-cell injection, SYS-6020.
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Multiple myeloma illustration
Biomarkers

lncMALAT1 behind multiple myeloma and its prognosis

June 18, 2024
Angiogenesis plays a crucial role in multiple myeloma and its prognosis, with the success of antiangiogenic therapies being limited. Exosomes mediate cell-to-cell cross talk during the progression of cancer by transporting their molecular cargo, which include long non-coding RNAs (lncRNAs); their role in multiple myeloma was investigated.
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CAR T cells attacking cancer cell
Immuno-oncology

Preclinical candidate KLN-1010 may address unmet needs in multiple myeloma

April 24, 2024
Multiple myeloma (MM) is still an uncurable disease. Chimeric antigen receptor (CAR) T cells directed to tumor necrosis factor receptor superfamily member 17, also known as BCMA, have transformed the field, with high response rate and durable remissions, but the access to this therapy is limited by multiple factors.
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