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Home » metastasis

Articles Tagged with ''metastasis''

Photo of magnifying glass inspecting moles on person's back
Biomarkers

INSM1 is highly sensitive marker in primary and metastatic Merkel cell carcinoma

April 4, 2025
The detection of metastases in Merkel cell carcinoma (MCC) requires additional testing, such as pancytokeratin (panCK) or CK20, with no guarantee of success. Recent findings have identified transcription factor SOX11 and insulinoma-associated protein 1 (INSM1) as sensitive nuclear neuroendocrine markers, but their usefulness in MCC has not been proven.
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Gastric cancer
Cancer

FXYD5 as therapeutic target to combat metastasis and drug resistance in gastric cancer

March 18, 2025
In recently published work from Air Force Medical University, analysis of tumor tissues isolated from different patient-derived xenografts revealed significantly increased expression of FXYD5 in the metastatic tumors compared to the primary tumors, and analysis of patient database confirmed significantly elevated expression of FXYD5 in gastric cancer tissues compared to normal gastric tissues.
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Small extracellular vesicle

Clots and metastasis in cancer patients start in the lung

Feb. 21, 2025
By Mar de Miguel
The lung and thrombosis may play a key role in cancer and metastasis progression, according to a collaborative study led by Cornell University scientists.
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Small extracellular vesicle
Cancer

Clots and metastasis in cancer patients start in the lung

Feb. 20, 2025
By Mar de Miguel
The lung and thrombosis may play a key role in cancer and metastasis progression, according to a collaborative study led by Cornell University scientists. In the nonmetastatic lung microenvironment of several cancer types, the development of a prothrombosis niche promotes metastasis formation through the release of small extracellular vesicles loaded with an integrin protein.
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Cancer

Origenis, Oncobone partner for cancer bone metastasis assets

Nov. 25, 2024
Oncobone Ventures Ltd. and Origenis GmbH have signed a framework agreement to develop novel therapies targeting cancer bone metastasis. Origenis leverages its artificial intelligence (AI)-driven technology platform Molmind-Moresystem-Brainstorm to design innovative targeted small-molecule therapies.
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3D illustration of tumor
Cancer

[131I]ICF-01012 demonstrates abscopal effect in innovative model

Oct. 25, 2024
The abscopal effect occurs when therapy leads to the regression of metastases distant from the target tumor. In the current study, researchers from INSERM aimed to evaluate the abscopal effect potentially inducted by the use the targeted radionuclide therapy (TRT) candidate, [131I]ICF-01012, which has been previously shown to target only pigmented metastases.
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AI-generated image for cancer cells observed under a microscope

Lung macrophages put invasive breast cancer cells to sleep

Oct. 15, 2024
By Xavier Bofill Bruna
Breast cancer cells, when disseminated to other secondary organs such as the lungs, may stay in a dormant state for years, even decades. But the mechanisms that limit their expansion are not well understood. This is what researchers call a dormant mesenchymal-like phenotype before metastasis to the lungs. Now, scientists have shown in a study published Oct. 7, 2024, in Cell, that the limiting of disseminated breast cancer cells (DCCs) to metastasize in the lungs is due to alveolar macrophages, which activate signals that make DCCs stay dormant.
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AI-generated image for cancer cells observed under a microscope
Cancer

Lung macrophages put invasive breast cancer cells to sleep

Oct. 14, 2024
By Xavier Bofill Bruna
Breast cancer cells, when disseminated to other secondary organs such as the lungs, may stay in a dormant state for years, even decades. But the mechanisms that limit their expansion are not well understood. This is what researchers call a dormant mesenchymal-like phenotype (M-like) before metastasis to the lungs. Now, scientists have shown in a study published Oct. 7, 2024, in Cell, that the limiting of disseminated breast cancer cells (DCCs) to metastasize in the lungs is due to alveolar macrophages (AMs), which activate signals that make DCCs stay dormant.
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Illustration of cancer cells entering the blood stream
Immuno-oncology

Mink Therapeutics and Autonomous Therapeutics target metastatic tumors through new collaboration

Oct. 9, 2024
Mink Therapeutics Inc. and Autonomous Therapeutics Inc. have announced a research collaboration aimed at targeting and treating metastatic tumors.
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Cancer

Zymedi patents new KARS/LR interaction inhibitors

Aug. 22, 2024
Zymedi Co. Ltd. has disclosed lysyl-tRNA synthetase (KARS)/laminin receptor (LR) interaction inhibitors reported to be useful for the treatment of cancer metastasis, autoimmune disease, inflammatory disorders, fibrosis and cardiovascular disorders.
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