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Home » metastasis

Articles Tagged with ''metastasis''

Cancer tumor in breast illustration
Cancer

Substance P neuropeptide promotes breast cancer metastasis

Aug. 12, 2024
By Anette Breindl
Researchers at Rockefeller University have identified a signaling loop between breast cancer cells and sensory neurons that promoted tumor metastasis, and showed that in animal models, treatment with the approved anti-nausea medication aprepitant could disrupt that loop.
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Scientific illustration of a migrating breast cancer cell
Cancer

HDAC inhibitor prevents breast cancer metastasis

July 30, 2024
Researchers from Northeast Normal University in Changchun demonstrated that compound AW-01178 reversed the abnormal regulation of E-cadherin by inhibiting the class I HDAC enzyme.
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Liver disease
Cancer

As target organ, liver can influence which metastases take

July 26, 2024
By Mar de Miguel
Not all cancer cells that detach from the primary tumor and embark on a journey to another organ colonize it. To establish themselves, cells need specific conditions. Scientists at the Federal Institute of Technology Zurich (ETH Zurich) explored this hypothesis in the liver and identified a protein involved in metastatic transformation. Blocking it prevented liver metastasis. Their findings may have applications in other organs and various types of cancers.
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Illustration of cancer cells entering the blood stream
Cancer

TWEAK signaling involved in metastasis in TNBC, study shows

July 19, 2024
Breast cancer is the leading cancer malignancy in women and triple-negative breast cancer (TNBC) is among the most aggressive types as it is insensitive to endocrine and HER2-targeted therapy because it lacks all three hormonal receptors.
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Dividing breast cancer cell.
Cancer

Isotoosendanin inhibits TNBC metastasis

July 19, 2024
Previous studies have demonstrated that the natural product isotoosendanin (ITSN) inhibited triple-negative breast cancer (TNBC) metastasis by preventing epithelial-mesenchymal transition (EMT) and lamellipodia formation regulated by the TGF-β–Smad2/3 signaling pathway in TNBC cells through directly binding to TGF-β receptor type 1 (TGF-βR1).
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Illustration showing layers of the meninges between the skull and brain
Cancer

Breast cancer metastases track vessels and neural signals to reach the brain

June 28, 2024
By Mar de Miguel
Breast cancer is a common cause of brain metastases and new research has shown that metastatic cells can invade the meninges not by entering the circulation and crossing the blood-brain barrier, but by traveling along the outer surface of the blood vessels that connect the vertebral bone marrow and the skull.
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Illustration of dividing cancer cells
Cancer

LARP4A and LARP4B behind osteosarcoma pathogenesis and metastasis to lung

May 3, 2024
RNA-binding proteins (RBPs) have emerged as interesting targets for cancer therapy. There is growing evidence that RBPs are dysregulated in cancer, usually with abnormal expression and/or with the presence of mutations.
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Illustration of cancer cells entering the bloodstream.
Cancer

AACR 2024: New concepts suggest new targets for metastatic disease

April 16, 2024
By Anette Breindl
Prior to this year’s Annual Meeting of the American Association for Cancer Research (AACR), it had been 14 years since metastasis had been the subject of a plenary session. So, the Tuesday session on “Evolution of the genome, microenvironment, and host through metastasis” had plenty of new insights to share.
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Illustration of cancer cells entering the bloodstream.
Cancer

AACR 2024: New concepts suggest new targets for metastatic disease

April 10, 2024
By Anette Breindl
Prior to this year’s Annual Meeting of the American Association for Cancer Research (AACR), it had been 14 years since metastasis had been the subject of a plenary session. So, the Tuesday session on “Evolution of the genome, microenvironment, and host through metastasis” had plenty of new insights to share.
Read More
Anatomy illustration of thyroid, tumor, cancer cells
Cancer

Targeting CDH4 blocks β-catenin signaling activation and inhibits metastasis

March 4, 2024
Researchers from Nanjing University and affiliated organizations have published the outcomes of a study that aimed to investigate the role of cadherin 4 (CDH4) in the metastatic cascade of papillary thyroid cancer (PTC).
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