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BioWorld - Sunday, May 25, 2025
Home » metastasis

Articles Tagged with ''metastasis''

Cancer

TCF4 genetic network behind melanoma resistance to immune checkpoint blockade

Jan. 16, 2024
Although treatment outcomes have improved in metastatic melanoma since the use of immune checkpoint blockade (ICB), it still remains a medical challenge. Melanoma cells are thought to adapt several phenotypic states, such as mesenchymal-like state (MES), which may modulate their sensitivity to therapy. An international team of researchers has now investigated the mechanisms behind melanoma cells’ resistance to ICB.
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Illustration of cancer cells entering the bloodstream.
Cancer

PIGT promotes bladder cancer metastasis through GLUT1 modulation

Jan. 5, 2024
Chinese investigators have unveiled a tumorigenic role for phosphatidylinositol glycan anchor biosynthesis class T (PIGT) in bladder cancer.
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Radiotherapy of cancer
Biomarkers

AIM2 is potential target in oral squamous cell carcinoma

Jan. 4, 2024
Radiotherapy resistance and metastasis are among the top risk factors for refractory oral squamous cell carcinoma (OSCC), the mechanisms of which must be elucidated, plus there is a lack of biomarkers to predict response.
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3D illustration of tumor
Cancer

Capital Medical University reports on first PAD4 inhibitors with PBA modification

Oct. 6, 2023
Protein-arginine deiminase type-4 (PAD4) protein contributes to the formation of neutrophil extranuclear traps (NETs), which in turn lead to tumor growth and cancer immune escape that favors metastatic disease. The expression of PAD4 in certain types of cells, such as hematopoietic stem cells, makes the strategy of PAD4 inhibition risky due to adverse side effects.
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Stem cell-derived vertebral bone with recruited breast cancer tumor cells
Musculoskeletal

The skeletal stem cell contains multitudes, with translational implications

Sep. 20, 2023
By Anette Breindl
Long bones, vertebrae and skull bones have distinct types of stem cells, and new insights into those stem cells could lead to new ways to treat both rare developmental disorders of skull formation and the all-too-common phenomenon of bone metastases. Scientifically, the work, which was published in two papers by Matthew Greenblatt and colleagues in Nature, adds to the increasing understanding of bone’s complexities. “Bone may serve as an endocrine organ that is secreting factors throughout the body,” Greenblatt said.
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Metastasis in mouse brain.
Cancer

Artificial intelligence classifies brain metastases via neuronal activity

Sep. 1, 2023
By Mar de Miguel
A Spanish study led by scientists from the Cajal Institute and the National Center of Oncological Research (CNIO) combined the power of artificial neural networks and biological neuronal circuits to identify abnormal brain activity produced by secondary metastases in the CNS and classify these tumors. The work, published online on Aug. 30, 2023, in Cancer Cell, showed how damage in the brain did not depend on the tumor size but on the effect it produced on neuronal circuits, interrupting cell communication.
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Cancer cell targeted in crosshairs
Cancer

SAL-98, a novel salinomycin derivative with promising antitumor and antimetastasis efficacy in vivo

July 28, 2023
Researchers from Kunming University of Science and Technology and affiliated organizations presented discovery and preclinical evaluation of a novel salinomycin derivative, SAL-98, as a potential therapeutic candidate for the treatment of cancer.
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Genequantum strikes deal for its ADC conjugation technology with Inxmed

July 18, 2023
By Tamra Sami
On the heels of a licensing deal last week, Genequantum Healthcare Co. Ltd. has struck another deal, this time out-licensing its conjugation technology to Inxmed Co. Ltd. to support development of next-generation targeted antibody-drug conjugates (ADCs).
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Illustration of man that is half human, half monster
Cancer

Intestinal T-cell type has Jekyll/Hyde roles in systemic immunosurveillance

June 13, 2023
By Subhasree Nag
Interactions between the gut microbiome and immune system influence cancer immune surveillance, though the mechanism through which these gut-primed immune cells regulate peripheral antitumor immune response is not well understood. Now, two recent studies in Science and Science Immunology using mouse models and human tissue samples have highlighted a group of intestinal T cells with the gut-homing α4β7 integrin receptors that play a critical role in mediating response to immune checkpoint blockade cancer immunotherapy.
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Cancer

Targeting mitochondria is strategy to fight brain metastases from breast cancer

June 1, 2023
By Anette Breindl
By interfering with mitochondrial plasticity, researchers have succeeded in attenuating brain metastases of HER2-expressing breast tumors. The authors wrote that their findings “highlight targeting mitochondrial dynamics is a viable therapeutic opportunity to limit both brain tumors and metastasis.”
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