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Home » metastasis

Articles Tagged with ''metastasis''

3D illustration showing tumor inside prostate gland and closeup view of cancer cells
Cancer

Targeting SYTL2-FSCN1-pseudopodia axis as new strategy in metastatic prostate cancer

May 16, 2023
Researchers from Sun Yat-Sen Memorial Hospital and affiliated organizations published data from a study that aimed to explore the mechanism of prostate cancer (PCa) metastasis to discover an intrinsic biomarker for metastatic PCa (mPCa).
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Cancer

RAB13 as key gene in metastasis-associated cell cluster and potential therapeutic target for ovarian cancer

May 3, 2023
Previous studies have shown that ovarian cancer (OC) has strong tumor heterogeneity, resulting in high recurrence and metastasis rates. In recently published work, researchers from Capital Medical University (CMU) applied single-cell transcriptomics to identify metastasis-associated cell clusters and key genes involved in OC metastasis.
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Cancer

NR2F2 isoform pushes melanoma into metastatic form

April 14, 2023
It is known that in melanoma, transformed melanocytic cells acquire stem cell-like features; these cells have multilineage differentiation potential, thus allowing them to morph into cell states with neural crest cell (NCC)-like, epithelial-to-mesenchymal transition-like features, promoting its metastatic potential.
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Breast cancer cells.
Cancer

OBSCN-AS1 and OBSCN identified as metastasis suppressors and new therapeutic targets in breast cancer

March 16, 2023
Previous studies have implicated OBSCN in breast tumorigenesis and have also demonstrated that low OBSCN levels correlate with significantly reduced overall and relapse-free survival in breast cancer patients. In a recent study, researchers from Memorial Sloan Kettering Cancer Center aimed to investigate the mechanisms involved in the regulation of OBSCN.
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Co-founders of Metsystem

Metsystem receives injection of funds to validate cancer metastasis prognosis platform

March 9, 2023
By Shani Alexander
Startup Metsystem ApS received €500,000 (US$529,080) from Denmark’s Bioinnovation Institute (BII) that will allow the company to conduct trials to validate its personalized prognosis platform for cancer metastasis. An organ-specific assessment of the metastasis potential of a patient’s primary tumor would enable clinicians to better balance the trade-off between providing the potentially life-extending benefit of preventative chemotherapy to those at higher risk and avoiding the adverse effects from chemotherapy in those who are unlikely to need it.
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Biomarkers

miR-371a-3p is overexpressed in metastatic seminomas and nonseminomas

Feb. 22, 2023
Recent findings unveiled that high serum levels of the molecular marker microRNA 371 correlate with the clinical stage and metastasis of seminomas (tumor of the testis germ cells) and nonseminomas. The expression of miR-371a-3p was evaluated in a cohort of patients with stage IIA/B seminoma and nonseminoma. Expression of miR-371a-3p was found to be positive in all 12 metastatic patients with seminoma or nonseminoma and was negative in 3 out of 4 nonmetastatic cases.
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Illustration of cancer cells entering the bloodstream.
Cancer

Nidogen-2 targeting reduces pancreatic cancer’s metastatic potential

Feb. 17, 2023
Pancreatic cancer still remains a highly lethal disease, with a 5-year survival rate of <10%. It is characterized by strong stromal activation leading to pro-tumorigenic extracellular matrix deposition. Recent findings in preclinical models have unveiled that targeting desmoplasia may improve chemotherapy efficacy and impede metastasis in pancreatic cancer.
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Immunofluorescence image of chromosomal instabilities
Cancer

Cancer’s chromosomal instability can be turned against itself

Feb. 16, 2023
By Mar de Miguel
In advanced or metastatic prostate cancer (PCa), patients may reach a stage where they do not respond to therapy. This stage is associated with chromosomal instability (CIN) and allow cells, up to a certain threshold, to adapt to therapy. However, a Mayo Clinic study has found a way to push that line so that cancer cells are so aberrant that they die.
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Dividing breast cancer cell.
Cancer

SULF1 knockdown seen to modulate TNBC metastatic potential

Feb. 15, 2023
Triple-negative breast cancer (TNBC) still remains as one of the most aggressive breast cancer types among women, with high metastatic potential and ability to shift towards epithelial-mesenchymal transition (EMT).
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Cancer

Tracking metastases by gene expression unveils four subtypes of cancer

Feb. 1, 2023
By Mar de Miguel
Cells that break away from a tumor and colonize other regions of the body express genes that are different from those of the cancer from which they originate. Now, a Baylor College of Medicine study has found that metastases can be classified into four cancer subtypes regardless of the primary cancer. This finding describes which genes are active in each one, making it possible to establish the most appropriate treatments for each patient according to the subtype of metastasis they have developed.
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