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Home » metastasis

Articles Tagged with ''metastasis''

Cancer

CARM1 cooperates with NFIB to promote SCLC development

Feb. 1, 2023
Coactivator-associated arginine methyl...
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Illustration of cancer in the bile ducts
Cancer

Hepatocyte’s secreted CCL3 promotes tumor metastasis in intrahepatic cholangiocarcinoma

Jan. 31, 2023
Intrahepatic cholangiocarcinoma (ICC) is a disease characterized by rapid progression, high relapse rate and high mortality.
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Melanoma cells stained with an H & E stain and magnified to 320x.
Cancer

LAP1 as prognostic marker and therapeutic target in human melanoma

Jan. 19, 2023
During metastasis, the mechanical properties of the nucleus make translocation of this organelle the rate-limiting step during constrained migration, and these properties are regulated through interactions between the cytoskeleton, integral nuclear envelope (NE) proteins, the nuclear lamina and chromatin.
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Cancer

Extracellular matrix plays key role in cancer initiation

Jan. 17, 2023
By W. Todd Penberthy
Pancreatic cancer is an exceptionally lethal cancer that is notoriously treatment resistant, in part due to poor vascularization in the tumor microenvironment. Investigators working at the Moores Cancer Center at the University of California, San Diego (UCSD), reported in the Jan. 16, 2023, issue of Nature Cell Biology on the discovery of a pathway that was initiated by isolation stresses (e.g., hypoxia, nutrient deprivation, and/or lack of extracellular matrix, ECM) leading to this cellular transformation in the tumor-initiating pancreatic cancer cell.
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Illustration of engineered T cells and tumor cell
‘22 in review

Progress in cancer, from brain metastases to cancer’s brain

Dec. 29, 2022
By Anette Breindl and Mar de Miguel
In 2022, neuroscience research made significant advances by understanding the role of large-scale neuronal connections in disorders. So did cancer research.
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Illustration of engineered T cells and tumor cell
Cancer

‘22 in review: Progress in cancer, from brain metastases to cancer’s brain

Dec. 29, 2022
By Anette Breindl and Mar de Miguel
In 2022, neuroscience research made significant advances by understanding the role of large-scale neuronal connections in disorders. So did cancer research.
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Photomicrograph of hepatocellular carcinoma
Biomarkers

EWSAT1 as novel prognosis marker and therapeutic target for hepatocellular carcinoma

Dec. 16, 2022
Researchers from Fudan University presented data from a study that aimed to assess the significance of a newly found long noncoding RNA (lncRNA), Ewing sarcoma-associated transcript 1 (EWSAT1), in hepatocellular carcinoma (HCC) metastasis.
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Breast cancer tumor and its microenvironment obtained from a live mouse model.
Cancer

PH-109 demonstrates antitumor activity in a mouse model of metastatic breast cancer

Nov. 29, 2022
Researchers from Phio Pharmaceuticals Corp. presented preclinical data for PH-109, a novel self-delivering RNAi targeting connective tissue growth factor (CTGF), which was originally developed and assessed in early clinical trials as potential treatment of dermal hypertrophic scarring and subretinal fibrosis. The current study evaluated PH-109 in a mouse model of metastatic breast cancer.
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Cancer and blood cells
Cancer

23C6 impairs metastatic outgrowth in breast and pancreatic cancer models

Nov. 16, 2022
Circulating tumor cells (CTCs) transit through the bloodstream and they exhibit heterogeneity in their expression of epithelial and mesenchymal marker proteins, including the cadherin proteins. Based on these findings, researchers from Massachusetts General Hospital and Harvard Medical School evaluated the potential of the dual anti-cadherin antibody, 23C6, in targeting CTC-dependent blood-borne metastasis.
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Cancer research illustration
Cancer

From mouse to man, UBR2 is target in cancer cachexia

Nov. 14, 2022
By W. Todd Penberthy
Investigators working at University of Texas Health Science Center, Houston, have discovered that the ubiquitin ligase UBR2 is up-regulated and sufficient for targeting the myosin heavy chain protein for the degradation characteristic of cancer cachexia. UBR2 knockout or pharmacological inhibition could prevent cachexia in mice. Confirmatory observations were noted in cancer cachexia patient-derived tissues.
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