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Home » Authors » Anette Breindl

Articles by Anette Breindl

Gut microbe enzymes can convert blood from type A to type O

June 12, 2019
By Anette Breindl
Scientists have discovered a pair of gut microbial enzymes that worked in tandem to convert blood cells of the type A to those of type O by removing the surface molecule alpha-1,3-linked-N-acetylgalactosamine (GalNAc) from the surface of red blood cells.
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Gut microbe enzymes can convert blood from type A to type O

June 11, 2019
By Anette Breindl
Scientists have discovered a pair of gut microbial enzymes that worked in tandem to convert blood cells of the type A to those of type O by removing the surface molecule alpha-1,3-linked-N-acetylgalactosamine (GalNAc) from the surface of red blood cells.
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Bench Press: BioWorld looks at translational medicine

June 10, 2019
By Anette Breindl
Scientists at University Hospital RWTH Aachen have trained a neural network to recognize microsatellite instability (MSI)-high gastrointestinal tumors directly from histology, without the need for genetic or immunochemistry testing. 
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Looking between the lines leads to neurofibromatosis insight

June 7, 2019
By Anette Breindl

POLO brings PARP to pancreas

June 4, 2019
By Anette Breindl
CHICAGO – Results from the phase III POLO trial presented at the 2019 American Society of Clinical Oncology's (ASCO's) 2019 annual meeting on Sunday showed that treatment with Lynparza (olaparib, Astrazeneca plc/Merck & Co Inc.) after platinum chemotherapy nearly doubled the progression-free interval (progression-free survival, PFS) in a group of 154 metastatic pancreatic cancer patients with germline BRCA mutations, from 3.8 to 7.4 months.
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Bench Press: BioWorld looks at translational medicine

June 3, 2019
By Anette Breindl
Scientists at the University of Edinburgh have demonstrated that they were able to restore learning abilities in a rat model of fragile X syndrome (FXS) through temporary treatment with the cholesterol-lowering agent lovastatin. 
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Looking between the lines leads to neurofibromatosis insight

May 29, 2019
By Anette Breindl
Characterized by large numbers of benign but highly disfiguring tumors, neurofibromatosis 1 (NF-1) is anything but a subtle disease. Because they are glaringly conspicuous, research into NF-1 has largely focused on the tumors themselves. But in the May 20, 2019, issue of PLoS ONE, researchers have reported new insights into the disease that stem from looking not at the tumors themselves but at tumor-free skin from NF-1 patients.
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Bench Press: BioWorld looks at translational medicine

May 28, 2019
By Anette Breindl
The words "crystal" and "healing" in the same sentence do not, by and large, connote solid scientific ground for the approach being advocated. But there is an exception to every rule, and researchers at Ghent University have described Charcot-Leyden crystals (CLCs) as a targetable feature of some allergic diseases. CLCs are made up of the protein galectin-10. 
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COX and LOX: For immune response, tolerance beats scorched-earth

May 23, 2019
By Anette Breindl
For the immune system, the self and non-self are something like the proverbial rock and a hard place. In order to be effective, the system as a whole needs to react vigorously to pathogens. But that vigorous reaction can also damage the organism it is meant to protect. The conundrum is on display in influenza infections.
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Bench Press: BioWorld looks at translational medicine

May 20, 2019
By Anette Breindl
Researchers at Stony Brook University have found a way to keep insulin-degrading enzyme (IDE) from deactivating insulin without affecting its role in degrading glucagon. 
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