An inhibitory protein that has been used for proof of principle of Myc inhibition through transgenic delivery was also able to inhibit Myc after intravenous delivery in animal models.
The innate immune protein NLRP6, which plays a protective role in inflammatory bowel disease (IBD), appears to aggravate intestinal graft-vs.-host disease (GVHD).
Long before any currently available detection method can find a tumor, the future patient's immune cells have found that tumor and are working on eliminating it. Now, researchers from Stanford University have developed a method to use such immune cells as sentinels, enabling earlier detection of tumors.
There are a number of so-called undruggable targets that have eluded attempts to find potent small-molecule compounds to affect their expression. One such protein is the oncogenic transcription factor Myc. Now, scientists from McGill University have developed a screen that could detect compounds that indirectly affect Myc expression.
The innate immune protein NLRP6, which plays a protective role in inflammatory bowel disease (IBD), appears to aggravate intestinal graft-vs.-host disease (GVHD).
SEATTLE – Clinical trial data for both approved and experimental HIV drugs were presented on the last day of the Conference on Retroviruses and Opportunistic Infections (CROI).
SEATTLE – Clinical trial data for both approved and experimental HIV drugs were presented on the last day of the Conference on Retroviruses and Opportunistic Infections (CROI).
Stimulator of interferon genes (STING) is an innate immune protein whose function is well described by its name. However, researchers at the University of Texas Southwestern Medical Center have discovered that STING also has a role in activating autophagy.
