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Home » Authors » Anette Breindl

Articles by Anette Breindl

MS joins diseases featuring protein aggregates

May 1, 2019
By Anette Breindl
Researchers have discovered that the synaptic protein Bassoon accumulated in the neurons of mice with experimental autoimmune encephalitis, the closest animal model to multiple sclerosis (MS), causing neuronal damage in much the same way that protein aggregates damage neurons in neurodegenerative diseases.
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Trio of trials gives glimpses into precision medicine's future

April 29, 2019
By Anette Breindl
Three phase I trials – I-PREDICT, TARGET and WINTHER – published back to back in the April 22, 2019, issue of Nature Medicine have reported progress on a central goal of precision medicine: the rapid delivery of therapy tailored to the molecular details of a patient's illness.
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Bench Press: BioWorld looks at translational medicine

April 29, 2019
By Anette Breindl
Researchers from Memorial Sloan-Kettering Cancer Center have identified the secondary bile acid lithocholic acid (LCA) as a contributor to a switch from individual growth to the formation of bacterial chains by the hospital-acquired pathogen vancomycin-resistant enterococci (VRE), and have shown that the formation of such chains facilitated biofilm formation and increased antibiotic resistance. 
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Bench Press: BioWorld looks at translational medicine

April 22, 2019
By Anette Breindl
Researchers from Albert Einstein Medical College and the University of Pittsburgh Medical Center have identified brain protective functions of recombinant tissue plasminogen activator (tPA) beyond its main effect of breaking down blood clots, and a compound that could target the same functions without affecting clotting.
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Sirtuin-6 DNA repair efficiency affects species life span

April 22, 2019
By Anette Breindl
Well, this sounds familiar: Researchers have identified a member of the sirtuin family that affected longevity. Across 18 different rodent species, those with more effective double-stranded break DNA repair – but not in nucleotide excision repair – by Sirtuin 6 (SIRT6) also had longer life spans.
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First-line gene therapy success reported for MB-107 in X-SCID

April 18, 2019
By Anette Breindl
Several infants treated with autologous ex vivo gene therapy for newly diagnosed X-linked severe combined immunodeficiency (X-SCID) in a phase I/II trial have developed fully functioning immune systems, including T cells, B cells and natural killer cells. The results, which were published in the April 17, 2019, issue of The New England Journal of Medicine, mark the first time that first-line treatment with X-SCID gene therapy has resulted in an immune system that was able to generate not just T cells, but the major cell types of the innate and adaptive immune systems.
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Bench Press: BioWorld looks at translational medicine

April 15, 2019
By Anette Breindl
Researchers at the University of Texas at Dallas have gained new insight into sex differences in response to calcitonin gene-related peptide (CGRP) that may underlie the higher prevalence of migraine in females. 
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Scientists: Noninvasive brain stimulation boosts working memory in older adults

April 9, 2019
By Anette Breindl

Noninvasive electrical brain stimulation boosts working memory in older adults

April 9, 2019
By Anette Breindl
Noninvasive electrical stimulation of the brain to synchronize the activity of distant cortical regions could boost the working memory of trial participants in their sixties to resemble a group of individuals in their twenties.
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Bench Press: BioWorld looks at translational medicine

April 8, 2019
By Anette Breindl
Scientists from Brigham and Women's Hospital have successfully targeted the enzyme myosin light chain kinase 1 (MLCK1) to improve the symptoms of inflammatory bowel disease, while avoiding the toxicity that has doomed previous approaches. 
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