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Home » Authors » Anette Breindl

Articles by Anette Breindl

With three NMOSD candidates, Devic's in the details

May 8, 2019
By Anette Breindl
PHILADELPHIA – "We've gone from no randomized controlled trial to three," Sean Pittock told reporters at the American Academy of Neurology (AAN) annual meeting this week. "It's a glorious example of what you can do with precision medicine."
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MS joins diseases featuring protein aggregates

May 8, 2019
By Anette Breindl
Researchers have discovered that the synaptic protein Bassoon accumulated in the neurons of mice with experimental autoimmune encephalitis, the closest animal model to multiple sclerosis (MS), causing neuronal damage in much the same way that protein aggregates damage neurons in neurodegenerative diseases.
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Huntington's hopefuls present at AAN 2019

May 7, 2019
By Anette Breindl
PHILADELPHIA – Data presented at the American Academy of Neurology (AAN) meeting this week on experimental therapeutics for Huntington's disease gave some cause for optimism. And, as good research does, they identified new questions as they answered current ones.
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Bench Press: BioWorld looks at translational medicine

May 6, 2019
By Anette Breindl
Researchers have linked the hormone oxytocin, which stimulates social and pair bonding, to the increased risk of aortic tear in women with Marfan syndrome. 
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Prion may be answer to Alzheimer's amyloid riddle

May 6, 2019
By Anette Breindl
"The molecular genetics for APP" – amyloid precursor protein – "still unequivocally demonstrate that APP and Abeta are crucial for disease pathogenesis" in Alzheimer's disease (AD), Carlo Condello told BioWorld.
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MS joins diseases featuring protein aggregates

May 1, 2019
By Anette Breindl
Researchers have discovered that the synaptic protein Bassoon accumulated in the neurons of mice with experimental autoimmune encephalitis, the closest animal model to multiple sclerosis (MS), causing neuronal damage in much the same way that protein aggregates damage neurons in neurodegenerative diseases.
Read More

Trio of trials gives glimpses into precision medicine's future

April 29, 2019
By Anette Breindl
Three phase I trials – I-PREDICT, TARGET and WINTHER – published back to back in the April 22, 2019, issue of Nature Medicine have reported progress on a central goal of precision medicine: the rapid delivery of therapy tailored to the molecular details of a patient's illness.
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Bench Press: BioWorld looks at translational medicine

April 29, 2019
By Anette Breindl
Researchers from Memorial Sloan-Kettering Cancer Center have identified the secondary bile acid lithocholic acid (LCA) as a contributor to a switch from individual growth to the formation of bacterial chains by the hospital-acquired pathogen vancomycin-resistant enterococci (VRE), and have shown that the formation of such chains facilitated biofilm formation and increased antibiotic resistance. 
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Bench Press: BioWorld looks at translational medicine

April 22, 2019
By Anette Breindl
Researchers from Albert Einstein Medical College and the University of Pittsburgh Medical Center have identified brain protective functions of recombinant tissue plasminogen activator (tPA) beyond its main effect of breaking down blood clots, and a compound that could target the same functions without affecting clotting.
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Sirtuin-6 DNA repair efficiency affects species life span

April 22, 2019
By Anette Breindl
Well, this sounds familiar: Researchers have identified a member of the sirtuin family that affected longevity. Across 18 different rodent species, those with more effective double-stranded break DNA repair – but not in nucleotide excision repair – by Sirtuin 6 (SIRT6) also had longer life spans.
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